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641 27f1b061f0a18681 2.31(c)(7)   1 Institutional Animal Care and Use Committee (IACUC). IACUC approval is not being secured prior to enacting significant changes in protocol #21-003 regarding the care and use of animals in ongoing activities. **The protocol describes blood sampling for all animals on the pregnancy studies (adult female olive baboons) as being performed under ketamine sedation at 2-4 day intervals depending on the treatment group. - In 2023, the daily treatment records for 17-year-old #07105 “Alissa” show that she underwent blood draws at daily intervals during multiple time periods. This includes, but is not limited to, daily blood draws during the following time periods: Jan 27th through January 30th, February 6th through Feb 11th, March 3rd through March 6th, 2023. - In 2021, the daily treatment records for 16-year-old #26876 “Jemma” show that she underwent blood draws at daily intervals during multiple time periods. This includes, but is not limited to, daily blood draws during the following time periods: May 12th through 15th, May 17th through 20th, May 23rd through 30th, June 10th through 13th. Increased blood draw frequency can have potential impacts on animal health and well-being and is a significant change to the current IACUC-approved protocol. ** The protocol states that all animals (adult female baboons) will be weighed monthly when they are on study. The protocol later states that animal weight is monitored weekly while the animal is on study when sedated. Records of 5 female baboons (ID #s: 26741, 26876, 27320, 07105, 03105) on the current protocol only have weights documented during their semi-annual physical and TB test, or during a surgical procedure. Upon request, no further documentation of animal weights during this study period could be provided by the facility. Monitoring the animal’s weight weekly is described in the protocol as a clinical parameter to be monitored to indicate adverse effects, pain, and/or distress to the animals. Failing to follow the protocol and significantly decreasing the frequency of weigh-ins without IACUC approval does not allow the IA…

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CREATE TABLE "citations" (
   [rowid] INTEGER PRIMARY KEY,
   [hash_id] TEXT REFERENCES [inspections]([hash_id]),
   [code] TEXT,
   [kind] TEXT,
   [repeat] INTEGER,
   [desc] TEXT,
   [narrative] TEXT
);
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