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20798 df18e2f90aa1bd59 2.31(c)(7)   0 INSTITUTIONAL ANIMAL CARE AND USE COMMITTEE (IACUC). Approved protocol 15-02 using rabbits describes the use of a Ketamine/Xylazine anesthetic cocktail to be administered IM or IV. Discussion with personnel conducting this procedure indicated the drug combination is actually given IP. Deviations from protocols related to minimizing pain and distress can be considered significant changes and shall be reviewed and approved by the IACUC prior to implementation. Consideration of topics for review might include appropriateness of route of drug administration according to established species guidelines. Correct by: Immediate
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