citation_inspection: 193

- A total of eight surgical biopsies are approved for animals enrolled on protocol #XXXXN000128. On June 10, 2021, a ninth biopsy procedure was performed on one animal enrolled on this protocol. Increasing the number of procedures constitutes a significant change to ongoing activities which was not reviewed and approved prior to being implemented. - An animal enrolled on IACUC approved protocol #XXXXN000018 had a surgical biopsy performed on Friday, May 20, 2022. The approved pain management plan on the protocol included the administration of a long-acting opioid and meloxicam daily 5 days post-procedure. The animal received analgesics per protocol on the day of surgery but did not receive meloxicam on May 21 or May 22, 2022. Failure to administer post-operative analgesia in accordance with the protocol constitutes a significant change that did not undergo IACUC review and approval. - IACUC approved protocol #XXXXN000020 includes the administration of immunosuppressive agents after a transplant procedure, up to six total doses. One animal received a transplant on July 27, 2022 and was subsequently treated with six doses of the immunosuppressive agents per protocol. On August 15, 2022, an additional dose was administered to the animal, which constituted a significant change that did not undergo IACUC review and approval. -A rabbit enrolled on IACUC approved protocol #XXXXN000015 underwent a study procedure on January 26, 2023. The monitoring schedule on the protocol includes twice daily monitoring for three days after the procedure. On January 27th, only one observation was performed. Failure to monitor animals in accordance with the protocol may compromise the ability of the researchers to detect problems of animal health and constitutes a significant change that did not undergo IACUC review and approval. These deviations from IACUC approved protocols were identified by the facility and voluntarily reported to USDA. Corrective measures had been implemented prior to inspection; to remain corrected after July 18th, 2023.