citation_inspection: 192

On September 8th, 2019, a cynomolgus macaque was found dead in its enclosure. Subsequent to a study procedure in August, monitoring of blood cell counts and body weight was conducted according to an approved protocol. Over the course of one week, there was a >80% decrease in the animal's white blood cell count to levels substantially lower than the normal reference range. These low levels persisted and continued to drop in two subsequent tests conducted over the course of the following week. Bi-weekly body weight measurements on this animal were documented and show steady and progressive weight loss over the same time period. Both of these parameters changing concurrently represent strong evidence that this animal was experiencing a health problem. However, the research team did not contact the facility veterinarian to provide timely and accurate information regarding the health and well-being of this animal, and the animal passed away without veterinary assessment or treatment. Research facilities shall maintain programs of veterinary care that include a mechanism of direct and frequent communication so that timely and accurate information on problems of animal health are conveyed to the veterinarian. This incident was voluntarily self-reported to the USDA by this facility, and corrective measures had been implemented prior to inspection. This inspection was conducted from December 16th to December 18th, with a preliminary exit interview conducted on site with facility representatives on December 18th. A final exit interview was conducted with facility representatives by phone on December 19th.