citation_inspection: 186

Protocol #IS1049-6 describes repeated administration of a compound. The approved protocol states that the compound is administered every 4 days, up to a maximum of 8 total doses. Animal #189-07 was administered the compound at 3 day intervals for a total of 9 doses between 5/11/2023 and 6/4/2023. Significant changes to approved protocols, such as increasing the number of total doses or changing frequency of doses, must be reviewed and approved by the IACUC. Animal #233-07, enrolled on protocol #IS1049-6, and animal #5-16, enrolled on protocol #IS888-6, were both undergoing water scheduling for training at the time of inspection. They were not weighed at the frequency approved in the protocols. The change to the weight monitoring schedule defined in the protocols was not reviewed and approved by the IACUC. The IACUC must review and approve significant changes regarding the use of animals in ongoing activities prior to implementation. Correct from June 29, 2023 forward. This inspection and exit interview were conducted with facility representatives. Additional Inspectors: SARA TOBIAS, VETERINARY MEDICAL OFFICER n